Associations of insulin-like growth factor binding protein-2 with metabolic profile and hepatic fat deposition in asymptomatic men and women
Chloé Rauzier, Dominic Chartrand, Natalie Alméras, Isabelle Lemieux, Éric Larose, Patrick Mathieu, Philippe Pîbarot, Benoı̂t Lamarche, Caroline Rhéaume, Paul Poirier, Jean‐Pierre Després, Frédéric Picard
Abstract
Faced with a paucity of reliable clinical etiologic markers for fatty liver, this research article demonstrates, for the first time, that low blood levels of the protein IGFBP-2 are associated with a more deteriorated cardiometabolic risk profile and with a high hepatic fat content independently of visceral fat volume and sex, even in asymptomatic, apparently healthy individuals.
Topics & Concepts
Internal medicineEndocrinologyInsulin resistanceMedicineDyslipidemiaAsymptomaticAdipose tissueTriglycerideInsulinBody mass indexFatty liverNonalcoholic fatty liver diseaseObesityCholesterolDiseaseLiver Disease Diagnosis and TreatmentGrowth Hormone and Insulin-like Growth FactorsLipid metabolism and disorders