Human Uterine Transplantation: A Review of Outcomes From the First 45 Cases
Benjamin P. Jones, Srdjan Saso, Timothy Bracewell‐Milnes, Meen‐Yau Thum, James Nicopoullos, César Díaz‐García, P Friend, Sadaf Ghaem‐Maghami, Giuliano Testa, Liza Johannesson, I Quiroga, J. Yazbek, James R. Smith
Abstract
( BJOG . 2019;126:1310–1319) Women with absolute uterine factor infertility (AUFI) cannot conceive or sustain pregnancy due to a dysfunctional uterus or absence of a uterus. Because adoption and surrogacy both have many limitations, researchers have developed uterine transplantation (UTx) as a potential solution for women with AUFI to conceive and deliver a genetically related child. After the first live birth following UTx occurred in 2014, obstetric researchers have published studies and collected detailed information on 45 different transplant cases, including 9 live births. This review compiles the data and outcomes from these 45 cases to note trends and make recommendations for best care practices.