TMPRSS2 and ACE2 Coexpression in SARS-CoV-2 Salivary Glands Infection
Lorella Pascolo, Luisa Zupin, M. Melato, Paola Maura Tricarico, Sérgio Crovella
Abstract
Xu et al. (2020) suggest that salivary glands are a potential target of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) infection, since the expression of angiotensin I–converting enzyme 2 (ACE2), the receptor needed for virus entry into host cells, was higher in salivary glands as compared with lung when the GTEx portal was queried.
Topics & Concepts
TMPRSS2Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakBetacoronavirusPandemicBiologyVirologySars virusPeptidyl-Dipeptidase AMedicineInternal medicineOutbreakDiseaseBlood pressureInfectious disease (medical specialty)Renin–angiotensin systemSARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testingCOVID-19 Clinical Research Studies