Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis
Jennifer M. Zupancic, Alec A. Desai, John S. Schardt, Ghasidit Pornnoppadol, Emily K. Makowski, Matthew D. Smith, Andrew A. Kennedy, Mayara Garcia de Mattos Barbosa, Marília Cascalho, Thomas M. Lanigan, Andrew W. Tai, Peter M. Tessier
Topics & Concepts
NeutralizationComputational biologyMutagenesisVirologyAntibodyBiologyDrug discoverySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Complementarity (molecular biology)Neutralizing antibodyBinding affinitiesComplementarity determining regionVirusChemistryCoronavirus disease 2019 (COVID-19)MutationGeneticsMonoclonal antibodyBiochemistryGeneReceptorInfectious disease (medical specialty)MedicinePathologyDiseaseSARS-CoV-2 and COVID-19 ResearchMonoclonal and Polyclonal Antibodies ResearchBacteriophages and microbial interactions