PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism

Hongyan Lin, Hongwei Han, Minkai Yang, Zhongling Wen, Qingqing Chen, Yudi Ma, Xuan Wang, Changyi Wang, Tongming Yin, Xiaoming Wang, Guihua Lu, Hong‐Yuan Chen, Jinliang Qi, Yonghua Yang, Yonghua Yang