Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides
Deli Sun, Guobin Ma, Xinluo Zhao, Chuanhu Lei, Hegui Gong
Abstract
We report an asymmetric Ni-catalyzed reductive cross-coupling of aryl/heteroaryl halides with racemic α-chlorosulfones to afford enantioenriched sulfones. The reaction tolerates a variety of functional groups under mild reaction conditions, which complements the current methods. The utility of this work was demonstrated by facile late-stage functionalization of commercial drugs.
Topics & Concepts
HalideArylNickelCatalysisReductive eliminationChemistryCombinatorial chemistryOrganic chemistryMedicinal chemistryAlkylSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsRadical Photochemical Reactions