Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors
Mariagrazia Rullo, Gabriella La Spada, Daniela Valeria Miniero, Andrea Gottinger, Marco Catto, Pietro Delre, Margherita Mastromarino, Tiziana Latronico, Sara Marchese, Giuseppe Felice Mangiatordi, Claudia Binda, Anna Linusson, Grazia Maria Liuzzi, Leonardo Pisani
Topics & Concepts
ChemistryIndazoleAmideNeuroprotectionBioisostereOxadiazoleMonoamine oxidase BStereochemistryDocking (animal)Combinatorial chemistryPharmacophoreEnzymeMonoamine oxidaseIn vitroBiochemistryChemical synthesisOrganic chemistryPharmacologyNursingMedicineParkinson's Disease Mechanisms and TreatmentsCholinesterase and Neurodegenerative DiseasesNeurotransmitter Receptor Influence on Behavior