Phosphine-catalyzed activation of cyclopropenones: a versatile C<sub>3</sub> synthon for (3+2) annulations with unsaturated electrophiles
Xin He, Pengchen Ma, Yuhai Tang, Jing Li, Shenyu Shen, Martin J. Lear, K. N. Houk, Silong Xu
Abstract
A phosphine-catalyzed (3 + 2) annulation of cyclopropenones with a wide variety of electrophilic π systems has been developed, in which an α-ketenyl phosphorous ylide is validated as the key intermediate used as a versatile C 3 synthon.
Topics & Concepts
SynthonElectrophileAnnulationPhosphineYlideCatalysisChemistryCombinatorial chemistryWittig reactionSubstrate (aquarium)Medicinal chemistryOrganic chemistryGeologyOceanographyCyclopropane Reaction MechanismsSynthetic Organic Chemistry MethodsCatalytic C–H Functionalization Methods