Visible-light-promoted denitrogenative <i>ortho</i>-selenylation reaction of benzotriazinones: synthesis of <i>ortho</i>-selenylated benzamides and ebselen analogs
Bo-Xi Liu, Fei Wang, Ying Chen, Weidong Rao, Shusu Shen, Shun‐Yi Wang
Abstract
A visible-light-promoted regioselective denitrogenative cross-coupling between benzotriazinones and selenosulfonates is reported. This protocol has been further applied to a one-pot two-step synthesis of a series of ebselen and its analogs.
Topics & Concepts
ChemistryEbselenRegioselectivityCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryCatalysisGlutathione peroxidaseEnzymeGlutathioneSulfur-Based Synthesis TechniquesOrganoselenium and organotellurium chemistryRadical Photochemical Reactions