IgG4-Mediated Neurologic Autoimmunities
Marinos C. Dalakas
Abstract
Describe the unique functions of immunoglobulin G4 (IgG4) in IgG4-neurologic disorders (IgG4-ND) and explain why, in contrast to their IgG1-counterparts, they respond poorly to intravenous immune globulin (IVIg) but effectively to anti-B cell therapies.
Topics & Concepts
ImmunologyAntibodyRituximabSubclassIsotypeMedicineImmune systemAntigenMonoclonal antibodyMyasthenia Gravis and ThymomaPeripheral Neuropathies and DisordersAutoimmune Neurological Disorders and Treatments