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Sensitizing solid tumors to CAR-mediated cytotoxicity by lipid nanoparticle delivery of synthetic antigens

Lena Gamboa, Ali Zamat, Chloé Thiveaud, Hee Jun Lee, Elif Kulaksizoglu, Zizhen Zha, N. Campbell, Ching Shen Chan, Sydney Fábrega, S. Oliver, Fang‐Yi Su, Hathaichanok Phuengkham, Daryll Vanover, Hannah E. Peck, Anirudh Sivakumar, Shreyas N. Dahotre, Adrian M. Harris, Philip J. Santangelo, Gabriel A. Kwong

2025Nature Cancer11 citationsDOIOpen Access PDF

Topics & Concepts

CytotoxicitySolid lipid nanoparticleNanoparticleChemistryCancer researchNanotechnologyBiochemistryBiologyMaterials scienceIn vitroCAR-T cell therapy researchRNA Interference and Gene DeliveryVirus-based gene therapy research
Sensitizing solid tumors to CAR-mediated cytotoxicity by lipid nanoparticle delivery of synthetic antigens | Litcius