The receptor-type protein tyrosine phosphatase CD45 promotes onset and severity of IL-1β–mediated autoinflammatory osteomyelitis
Jarmila Králová, Наталія Павлюченко, Matej Fabišik, Kristýna Ilievová, František Špoutil, Jan Procházka, Jana Pokorná, Radislav Sedláček, Tomáš Brdička
Abstract
neutrophils that are attenuated by CD45 deficiency. These data suggest a role for SFKs in autoinflammation. Together with previously published work on the involvement of protein tyrosine kinase spleen tyrosine kinase, they point to the role of receptors containing immunoreceptor tyrosine-based activation motifs, which after phosphorylation by SFKs recruit spleen tyrosine kinase for further signal propagation. We propose that this class of receptors triggers the events resulting in increased pro-IL-1β synthesis and disease initiation and/or progression.
Topics & Concepts
Protein tyrosine phosphataseTRIFReceptor tyrosine kinaseBiologyPhosphorylationSignal transductionCell biologySignal transducing adaptor proteinImmunologyTyrosine phosphorylationInflammationProto-oncogene tyrosine-protein kinase SrcReceptorCancer researchToll-like receptorInnate immune systemBiochemistryImmune systemInflammasome and immune disordersProtein Tyrosine PhosphatasesImmune Response and Inflammation