Envelope Stress and Regulation of the <i>Salmonella</i> Pathogenicity Island 1 Type III Secretion System
Alexander D. Palmer, James M. Slauch
Abstract
Salmonella causes worldwide foodborne illness, leading to massive disease burden and an estimated 600,000 deaths per year. Salmonella infects orally and invades intestinal epithelial cells using a type 3 secretion system that directly injects effector proteins into host cells. This first step in invasion is tightly regulated by a variety of inputs. In this work, we demonstrate that Salmonella senses the functionality of outer membrane assembly in determining regulation of invasion machinery, and we show that Salmonella uses distinct mechanisms to detect specific perturbations in envelope assembly.
Topics & Concepts
SalmonellaBiologySecretionEffectorPathogenicity islandType three secretion systemEnvelope (radar)PathogenicityMicrobiologyBacterial outer membraneCell biologyEscherichia coliBacteriaGeneticsVirulenceBiochemistryGeneTelecommunicationsComputer scienceRadarSalmonella and Campylobacter epidemiologyEscherichia coli research studiesVibrio bacteria research studies