Targeting copper metabolism to defeat KRAS-driven colorectal cancer
Léo Aubert, Neethi Nandagopal, Philippe P. Roux
Abstract
KRAS-driven cancers acquire profound metabolic dependencies that are intimately linked to tumor growth. Our work revealed that colorectal cancers that harbor KRAS mutations are addicted to copper metabolism. This adaptation renders tumor cells critically dependent on the copper transporter ATP7A, which reveals copper metabolism as a promising therapeutic target for KRAS-driven colorectal cancers.
Topics & Concepts
KRASColorectal cancerCancer researchMetabolismTransporterMetabolic adaptationCopper metabolismCopperMedicineBiologyInternal medicineCancerChemistryGeneGeneticsOrganic chemistryTrace Elements in HealthDrug Transport and Resistance MechanismsPharmacological Effects and Toxicity Studies