Mechanisms of Caloric Restriction-Mediated Stress-Resistance in Acute Kidney Injury
Felix C. Koehler, Martin R. Späth, Karla Johanna Ruth Hoyer-Allo, Roman‐Ulrich Müller
Abstract
Caloric restriction (CR)-mediated organ protection has been shown to be extremely efficient in rodent models of acute kidney injury (AKI). Limited understanding of the underlying mechanisms paired with a risk of malnourishment and feasibility problems has hindered the translation of this immense potential to the patient setting. In this mini-review, the current mechanistic concepts of CR-mediated stress-resistance as potential key targets for renal protection in AKI will be highlighted.
Topics & Concepts
MedicineAcute kidney injuryCaloric theoryIntensive care medicineKidneyMalnutritionNephrologyBioinformaticsInternal medicineBiologyMitochondrial Function and PathologyElectrolyte and hormonal disordersTryptophan and brain disorders