Prophylactic Cranial Irradiation for Small-Cell Lung Cancer: Time for a Reassessment
Martin J. Edelman
Abstract
Prophylactic cranial irradiation (PCI) has been an accepted part of the management of both limited and small-cell lung cancer; however, the data that support its use in limited-stage disease is based on an analysis of trials done before currently accepted approaches to staging (i.e., brain MRI and/or PET scanning) were available. For extensive disease, data are available from two randomized studies that are in direct conflict. This article explores the basic rationale for PCI and the evidence indicating that it is time to readdress the question of its routine use.
Topics & Concepts
Prophylactic cranial irradiationConventional PCIMedicineLung cancerRandomized controlled trialDiseaseRadiologyMedical physicsSurgeryOncologyPathologyInternal medicineMyocardial infarctionLung Cancer Research StudiesNeuroendocrine Tumor Research AdvancesBrain Metastases and Treatment