First-in-human liver transplantation from a centenarian deceased donor after brain death
Paolo De Simone, Davide Ghinolfi, Simona Palladino, Gabriele Catalano, Caterina Martinelli, Juri Ducci, Jessica Bronzoni, Giovanni Tincani, E Balzano, Paola Carrai, Stefania Petruccelli, Daniela Campani, Laura Crocetti, Chiara Lazzeri, Gíanni Biancofiore, Adriano Peris
Abstract
Liver transplantation from elderly donors is expanding due to demand for liver grafts, aging of recipients and donors, and introduction of machine perfusion. We report on a liver transplant from a 100-year-old deceased donor after brain death. The liver was transplanted after the use of hypothermic machine perfusion to a 60-year-old recipient with advanced hepatocellular carcinoma undergoing neoadjuvant immunotherapy. Nine months after the transplant, the patient is alive with a functioning graft and no evidence of acute rejection or tumor recurrence.