Recent Advances in Aptasensor for Cytokine Detection: A Review
Jinmyeong Kim, Seungwoo Noh, Jeong Ah Park, Sang Chan Park, Seong Jun Park, Jin‐Ho Lee, Jae‐Hyuk Ahn, Taek Lee
Abstract
Cytokines are proteins secreted by immune cells. They promote cell signal transduction and are involved in cell replication, death, and recovery. Cytokines are immune modulators, but their excessive secretion causes uncontrolled inflammation that attacks normal cells. Considering the properties of cytokines, monitoring the secretion of cytokines in vivo is of great value for medical and biological research. In this review, we offer a report on recent studies for cytokine detection, especially studies on aptasensors using aptamers. Aptamers are single strand nucleic acids that form a stable three-dimensional structure and have been receiving attention due to various characteristics such as simple production methods, low molecular weight, and ease of modification while performing a physiological role similar to antibodies.