Nitric oxide imaging in cancer enabled by steric relaxation of a photoacoustic probe platform
Christopher J. Reinhardt, Ruiwen Xu, Jefferson Chan
Abstract
Systematic optimization of the aza-BODIPY dye platform facilitated planarization and a red-shift in the absorbance. SR-APNO-3 enabled the first validated detection of cancer-derived nitric oxide with PA imaging.
Topics & Concepts
Photoacoustic imaging in biomedicineNitric oxideAbsorbanceSteric effectsOxideChemistryNanotechnologyMaterials sciencePhotochemistryBiophysicsOrganic chemistryOpticsChromatographyBiologyPhysicsNanoplatforms for cancer theranosticsPhotoacoustic and Ultrasonic ImagingAnalytical Chemistry and Sensors