IL-33/ST2 induces macrophage-dependent ROS production and TRPA1 activation that mediate pain-like responses by skin incision in mice
Ruoyao Xu, Yushuang Pan, Kaige Zheng, Muyan Chen, Chengyu Yin, Qimiao Hu, Jie Wang, Qing Yu, Peiyi Li, Yan Tai, Junfan Fang, Boyu Liu, Jianqiao Fang, Guihua Tian, Boyi Liu
Abstract
Our work uncovered a previously unrecognized contribution of IL-33/ST2 signaling in mediating mechanical allodynia and gait impairment of a mouse model of INC pain. Targeting IL-33/ST2 signaling could be a novel therapeutic approach for INC pain management.
Topics & Concepts
MacrophageChemistryCell biologyBiologyBiochemistryIn vitroDermatology and Skin DiseasesAsthma and respiratory diseasesIL-33, ST2, and ILC Pathways