Oleanolic acid inhibits M2 macrophage polarization and potentiates anti-PD-1 therapy in hepatocellular carcinoma by targeting miR-130b-3p-PTEN-PI3K-Akt signaling and glycolysis
Xiaoyu Tu, Wanfu Lin, Xiaofeng Zhai, Shufang Liang, Guokai Huang, Jingfang Wang, Wentao Jia, Shu Li, Bai Li, Binbin Cheng
Topics & Concepts
PTENOleanolic acidHepatocellular carcinomaPI3K/AKT/mTOR pathwayProtein kinase BCancer researchGlycolysisChemistryMacrophage polarizationPharmacologyMedicinePhosphorylationMacrophageBiochemistryApoptosisMetabolismPathologyIn vitroAlternative medicineImmune cells in cancerGenomics, phytochemicals, and oxidative stressNatural product bioactivities and synthesis