The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins
Olivier Touzelet, Lindsay Broadbent, Stuart D. Armstrong, Waleed Aljabr, Elaine Cloutman-Green, Ultan F. Power, Julian A. Hiscox
Abstract
using BEAS-2B cells. hRSV infection disrupted the polarity of the pediatric respiratory epithelial secretome and was associated with immune modulating proteins (CXCL6, CXCL16, CSF3) never linked with this virus before. In addition, the antiviral activity of CEACAM1 against hRSV had also never been previously characterized. This study, therefore, provides novel insights into RSV pathogenesis and endogenous antiviral responses in pediatric airway epithelium.
Topics & Concepts
Immune systemBiologyCXCL16ChemokineCell biologyImmunologyRespiratory epitheliumVirologyEpitheliumGeneticsCXCL10Respiratory viral infections researchInfluenza Virus Research StudiesMonoclonal and Polyclonal Antibodies Research