<i>In vitro</i> evidence of oncofetal antigen and TLR-9 agonist co-delivery by alginate nanovaccines for liver cancer immunotherapy
Mengyue Pei, Huiyang Li, Yingwei Zhu, Jian Lü, Chuangnian Zhang
Abstract
histocompatibility showed that APPC was non-toxic within the tested concentration. This study demonstrates that the peptide antigen and the CpG adjuvant co-delivery nanovaccine have potential applications in liver cancer immunotherapy.
Topics & Concepts
AdjuvantAntigenCancer immunotherapyImmunotherapyIn vivoIn vitroCancer researchCytotoxic T cellCpG OligodeoxynucleotideChemistryTumor antigenBiologyImmune systemMolecular biologyImmunologyBiochemistryGene expressionBiotechnologyGeneDNA methylationImmunotherapy and Immune ResponsesRNA Interference and Gene DeliveryNanoplatforms for cancer theranostics