Review of Synthetic Routes and Crystalline Forms of the Antiandrogen Oncology Drugs Enzalutamide, Apalutamide, and Darolutamide
David L. Hughes
Abstract
This article reviews the synthetic routes and final crystalline forms of the recently approved antiandrogen drugs enzalutamide, apalutamide, and darolutamide, used for the treatment of prostate cancer. The patent literature was the primary source of information.
Topics & Concepts
EnzalutamideAntiandrogenProstate cancerMedicinePharmacologyOncologyInternal medicineCancerAndrogen receptorProstate Cancer Treatment and ResearchRadiopharmaceutical Chemistry and ApplicationsPharmacogenetics and Drug Metabolism