Plumbagin attenuates traumatic tracheal stenosis in rats and inhibits lung fibroblast proliferation and differentiation via TGF-β1/Smad and Akt/mTOR pathways
Wei Shi, Yuanyuan Fang, Yue‐Ming Jiang, Siyang Jiang, Yu Li, Wentao Li, Mingpeng Xu, Michael Aschner, Guangnan Liu
Abstract
. Furthermore, PLB reduced the degree of TS in rats. Taken together, our results indicate that PLB regulates lung fibroblast activity and attenuates TS in rats by inhibiting TGF-β1/Smad and Akt/mTOR signaling pathways. In conclusion, this study implies that PLB may serve as a promising therapeutic compound for TS.
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BIn vivoSMADChemistryPlumbaginSignal transductionCell biologyFibroblastLY294002Cancer researchBiologyIn vitroBiochemistryGeneticsBiotechnologyBioactive Compounds and Antitumor AgentsEchinoderm biology and ecologyInfectious Diseases and Mycology