Clearance of Clostridioides difficile Colonization Is Associated with Antibiotic-Specific Bacterial Changes
Nicholas A. Lesniak, Alyxandria M. Schubert, Hamide Sinani, Patrick D. Schloss
Abstract
The community of microorganisms, or microbiota, in our intestines prevents pathogens like C. difficile from colonizing and causing infection. However, antibiotics can disturb the gut microbiota, which allows C. difficile to colonize. C. difficile infections (CDI) are primarily treated with antibiotics, which frequently leads to recurrent infections because the microbiota has not yet returned to a resistant state.
Topics & Concepts
ClostridioidesAntibioticsColonizationMicrobiologyBiologyC difficileGut floraColonisation resistanceClostridium difficileImmunologyClostridium difficile and Clostridium perfringens researchGut microbiota and healthGastrointestinal motility and disorders