Berberine impairs coxsackievirus B3‐induced myocarditis through the inhibition of virus replication and host pro‐inflammatory response
Qian Dai, Xiaomei He, Hua Yu, Ying Bai, Lu Jiang, Halei Sheng, Jin Peng, Maolin Wang, Jiang Yu, Kebin Zhang
Abstract
Berberine (BBR), an isoquinoline alkaloid isolated from Rhizoma coptidis, is reported to possess antiviral activity. Our previous study has shown that BBR alleviates coxsackievirus B3 (CVB3) replication in HeLa cells. However, the anti-CVB3 activity of BBR is still unclear in vivo. In this study, we explored the effect of BBR on CVB3-induced viral myocarditis in mice. These results demonstrated the beneficial effect of BBR on alleviating CVB3-induced myocarditis in vivo, which sheds new light on the utility of BBR as a therapeutic strategy against CVB3-induced viral myocarditis.
Topics & Concepts
BerberineMyocarditisIn vivoViral replicationVirusViral MyocarditisVirologyCoxsackievirusHeLaChemistryBiologyIn vitroPharmacologyEnterovirusMedicineBiochemistryBiotechnologyCardiologyViral Infections and Immunology ResearchRNA and protein synthesis mechanismsAntimicrobial Resistance in Staphylococcus