Ferrocene-liposome-PEG: a robust ˙OH/lipid peroxide nano-converter for inducing tumor ferroptosis
Yang Liu, Jinzhu Chen, Zi He, Huiling Luo, Xinxin Liu, Xinxin Liu, Yanan Sun, Dongtao Ge, Xin Liu, Xin Liu, Wei Shi
Abstract
therapeutic outcomes showed the high tumor inhibition ratio (74.0%) and the low side effects of Fc-Lp-PEG on 4T1 tumor-bearing mice. This novel strategy for improving the ˙OH/LPO conversion efficiency might provide new insights for the clinical development of ferroptosis-based CDT.
Topics & Concepts
ChemistryLiposomeLipid peroxidationPhospholipidReactive oxygen speciesRadicalLipid peroxideBiophysicsLipid bilayerPEG ratioBiochemistryPeroxideIn vivoMembraneCombinatorial chemistryOxidative stressOrganic chemistryBiologyBiotechnologyFinanceEconomicsFerroptosis and cancer prognosisNanoplatforms for cancer theranosticsCancer, Lipids, and Metabolism