The American lifestyle-induced obesity syndrome diet in male and female rodents recapitulates the clinical and transcriptomic features of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Shelley Harris, Toryn Poolman, Anastasia Arvaniti, Roger Cox, Laura Gathercole, Jeremy Tomlinson
2020American Journal of Physiology-Gastrointestinal and Liver Physiology33 citationsDOIOpen Access PDF
Abstract
Nonalcoholic fatty liver disease (NAFLD) affects 30% of the general population and can progress to nonalcoholic steatohepatitis (NASH) and potentially hepatocellular carcinoma. Preclinical models rely on mouse models that often display hepatic characteristics of NAFLD but rarely progress to NASH and seldom depict the multisystem effects of the disease. We have conducted comprehensive metabolic analysis of both male and female mice consuming a Western diet of trans fats and sugar, focusing on both their hepatic phenotype and extrahepatic manifestations.
Topics & Concepts
Nonalcoholic fatty liver diseaseNonalcoholic steatohepatitisDiseaseObesityMedicineMetabolic syndromeFatty liverInternal medicineTranscriptomeSteatohepatitisGastroenterologyPathologyBiologyGeneGene expressionBiochemistryLiver Disease Diagnosis and TreatmentDiet, Metabolism, and DiseaseDiet and metabolism studies