Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice
Yipeng Sui, Zhaojie Meng, Sehyung Park, Weiwei Lu, Christopher Livelo, Qi Chen, Tong Zhou, Changcheng Zhou
Abstract
mice. Further, RNA-Seq analysis indicated that treatment with a prototypical PXR ligand affects the expression of many atherosclerosis-related genes in macrophages in vitro. These findings reveal a pivotal role of myeloid PXR signaling in atherosclerosis development and suggest that PXR may be a potential therapeutic target in atherosclerosis management.
Topics & Concepts
Pregnane X receptorCD36ReceptorLDL receptorLipid metabolismScavenger receptorFoam cellNuclear receptorInternal medicineChemistryEndocrinologyBiologyCell biologyCholesterolLipoproteinBiochemistryMedicineTranscription factorGeneCholesterol and Lipid MetabolismHormonal Regulation and HypertensionEstrogen and related hormone effects