Efficacy of Omadacycline-Containing Regimen in a Mouse Model of Pulmonary Mycobacteroides abscessus Disease
Binayak Rimal, Danielle A. Nicklas, Chandra M. Panthi, Christopher K. Lippincott, Daniel C. Belz, Elisa H. Ignatius, Daniel Deck, Alisa W. Serio, Gyanu Lamichhane
Abstract
M. abscessus disease incidence is increasing in the United States. This disease is difficult to cure with existing antibiotics. In this study, we describe the efficacy of a new tetracycline antibiotic, omadacycline, in combination with an existing antibiotic to treat this disease. A mouse model of M. abscessus lung disease was used to assess the efficacies of these experimental treatment regimens. Omadacycline in combination with select existing antibiotics exhibited bactericidal activity during the early phase of treatment.
Topics & Concepts
RegimenPulmonary diseaseMedicineInternal medicineChemistryMycobacterium research and diagnosisTuberculosis Research and EpidemiologyInfectious Diseases and Mycology