NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection
Madhumanti Dasgupta, Meghana Shashikanth, Anjali Gupta, Anjali Sandhu, Atreyee De, Salil Javed, Varsha Singh
Abstract
Immune response to pathogens is energetically expensive to the host; however, the cellular source of energy to fuel immune response remains unknown. In this study, we show that Caenorhabditis elegans exposed to pathogenic Gram-positive and Gram-negative bacteria or yeast rapidly utilizes lipid droplets, the major energy reserve. The nematode’s response to the pathogenic bacterium Enterococcus faecalis entails metabolic rewiring for the upregulation of several genes involved in lipid utilization and downregulation of lipid synthesis genes.
Topics & Concepts
BiologyCaenorhabditis elegansEnterococcus faecalisImmune systemMicrobiologyDownregulation and upregulationBacteriaTranscription factorLipid metabolismGeneImmunologyGeneticsStaphylococcus aureusBiochemistryGenetics, Aging, and Longevity in Model OrganismsGut microbiota and healthCircadian rhythm and melatonin