Regeneration of Tumor-Antigen-Specific Cytotoxic T Lymphocytes from iPSCs Transduced with Exogenous TCR Genes
Takuya Maeda, Seiji Nagano, Soki Kashima, Koji Terada, Yasutoshi Agata, Hiroshi Ichise, Manami Ohtaka, Mahito Nakanishi, Fumihiro Fujiki, Haruo Sugiyama, Toshio Kitawaki, Norimitsu Kadowaki, Akifumi Takaori‐Kondo, Kyoko Masuda, Hiroshi Kawamoto
Abstract
model. These results collectively demonstrate the feasibility of the TCR-iPSC strategy.
Topics & Concepts
Cytotoxic T cellT-cell receptorRegeneration (biology)GeneAntigenBiologyInduced pluripotent stem cellCancer researchCell biologyMolecular biologyImmunologyT cellGeneticsImmune systemIn vitroEmbryonic stem cellCAR-T cell therapy researchImmunotherapy and Immune ResponsesMonoclonal and Polyclonal Antibodies Research