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The small molecule chemical compound cinobufotalin attenuates resistance to DDP by inducing ENKUR expression to suppress MYH9-mediated c-Myc deubiquitination in lung adenocarcinoma

Jiahao Liu, Huiling Yang, Shuting Deng, Zhe Hu, Weifeng Chen, Weiwei Yan, Rentao Hou, Yonghao Li, Ruiting Xian, Yingying Xie, Yun Su, Liyang Wu, Ping Xu, Zhibo Zhu, Xiong Liu, Yuling Deng, Yubing Wang, Zhen Liu, Weiyi Fang

2022Acta Pharmacologica Sinica39 citationsDOIOpen Access PDF

Topics & Concepts

Downregulation and upregulationCancer researchProtein kinase BChemistryTranscription factorCisplatinUbiquitinEpithelial–mesenchymal transitionMolecular biologyBiologySignal transductionBiochemistryGeneChemotherapyGeneticsUbiquitin and proteasome pathwaysCancer, Hypoxia, and MetabolismCancer-related Molecular Pathways
The small molecule chemical compound cinobufotalin attenuates resistance to DDP by inducing ENKUR expression to suppress MYH9-mediated c-Myc deubiquitination in lung adenocarcinoma | Litcius