NRG4-ErbB4 signaling represses proinflammatory macrophage activity
Michael A. Schumacher, Isabella Dennis, Cambrian Y. Liu, Cache Robinson, Judie Shang, Jessica K. Bernard, M. Kay Washington, D. Brent Polk, Mark R. Frey
2021American Journal of Physiology-Gastrointestinal and Liver Physiology32 citationsDOIOpen Access PDF
Abstract
Proinflammatory macrophages are essential drivers of colitis and express the growth factor receptor ErbB4. This study tested the role of ErbB4 and its specific ligand, NRG4, in regulating macrophage function. We show that endogenous NRG4-ErbB4 signaling limits macrophage production of proinflammatory cytokines in vitro and limits colitis severity in vivo and thus is a potential target for therapeutic intervention.
Topics & Concepts
Proinflammatory cytokineMacrophageERBB4InflammationCell biologySignal transductionCancer researchImmunologyMedicineChemistryBiologyIn vitroBiochemistryReceptor tyrosine kinaseHelicobacter pylori-related gastroenterology studiesCytokine Signaling Pathways and InteractionsGalectins and Cancer Biology