Germline CRISPR/Cas9-Mediated Gene Editing Prevents Vision Loss in a Novel Mouse Model of Aniridia
Seyedeh Zeinab Mirjalili Mohanna, Jack W. Hickmott, Siu Ling Lam, Nina Y. Chiu, Tess C. Lengyell, Beatrice M. Tam, Orson L. Moritz, Elizabeth M. Simpson
Abstract
mutation alone rescues the mutant phenotype, and developed an allele-distinguishing CRISPR-based strategy for aniridia.
Topics & Concepts
CRISPRAniridiaGermlineGenome editingGeneticsBiologyCas9PAX6GeneTranscription factorCRISPR and Genetic EngineeringRetinal Development and DisordersGenetics, Aging, and Longevity in Model Organisms