Healthy First-Degree Relatives From Multiplex Families vs Simplex Families Have Higher Subclinical Intestinal Inflammation, a Distinct Fecal Microbial Signature, and Harbor a Higher Risk of Developing Crohn’s Disease

Pablo A. Olivera, Helena Martínez-Lozano, Haim Leibovitzh, Mingyue Xue, Anna Neustaeter, Osvaldo Espin‐Garcia, Wei Xu, Karen Madsen, David S. Guttman, Çharles N. Bernstein, Baruch Yerushalmi, Jeffrey S. Hyams, Maria T. Abreu, John K. Marshall, Iwona Wrobel, David R. Mack, Kevan Jacobson, Alain Bitton, Guy Aumais, Remo Panacionne, Levinus A. Dieleman, Mark S. Silverberg, A. Hillary Steinhart, Paul Moayyedi, Dan Turner, Anne M. Griffiths, Williams Turpin, Sun-Ho Lee, Kenneth Croitoru, Kenneth Croitoru, Maria T. Abreu, Paul Beck, Charles Bernstein, Kenneth Croitoru, Kenneth Croitoru, Levinus Dieleman, Brian Feagan, Anne Griffiths, David S. Guttman, Kevan Jacobson, Gilaad Kaplan, Denis O. Krause, Karen L. Madsen, John K. Marshall, Paul Moayyedi, Mark Ropeleski, Ernest Seidman, Mark S. Silverberg, Scott Snapper, Andy Stadnyk, A. Hillary Steinhart, Michael Surette, Dan Turner, Thomas Walters, Bruce Vallance, Guy Aumais, Alain Bitton, Maria Cino, Jeff Critch, Lee Denson, Colette Deslandres, Wael El-Matary, Hans Herfarth, Peter Higgins, Hien Q. Huynh, Jeff Hyams, David R. Mack, Jerry McGrath, Anthony Otley, Remo Panaccione