Ir-Catalyzed cyclization of α,ω-dienes with an <i>N</i>-methyl group <i>via</i> two C–H activation steps
Katsumasa Tanaka, Hiroshi Hattori, Ryota Yabe, Takahiro Nishimura
Abstract
-methyl group with a vinyl moiety and subsequent intramolecular cyclization at the β-position of the initially formed alkylated intermediate. The reaction using a chiral bidentate phosphine ligand enabled the asymmetric synthesis of the cyclic compounds.
Topics & Concepts
ChemistryIridiumAlkylationMoietyPhosphineCatalysisIntramolecular forceMedicinal chemistryDenticityMethyl groupLigand (biochemistry)Intermolecular forceStereochemistryGroup (periodic table)Organic chemistryCrystal structureMoleculeBiochemistryReceptorCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCatalytic Cross-Coupling Reactions