A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum
Jansy P. Sarathy, Min Xie, R. Mark Jones, Adrienne Chang, Paulina Osiecki, Danielle Weiner, Wen-Shan Tsao, Maureen Dougher, Landry Blanc, Nader Fotouhi, Laura E. Via, Clifton E. Barry, Iwijn De Vlaminck, David R. Sherman, Véronique Dartois
Abstract
. The assay is well suited to screen for bactericidal compounds against caseum-resident Mtb in a medium-throughput format, allowing for reduced reliance on resource intensive animal models that present large necrotic lesions and cavities. Importantly, this approach will aid the identification of vulnerable targets in caseum Mtb and can accelerate the development of novel TB drugs with treatment-shortening potential.
Topics & Concepts
TuberculosisDrugPopulationMycobacterium tuberculosisDrug resistanceMedicineMicrobiologyBiologyComputational biologyPharmacologyPathologyEnvironmental healthTuberculosis Research and EpidemiologyMycobacterium research and diagnosisHIV/AIDS drug development and treatment