NLRP3 inflammasome inhibition with MCC950 improves insulin sensitivity and inflammation in a mouse model of frontotemporal dementia
Claire Hull, Ruta Dekeryte, Heather Buchanan, Sarah Kamli-Salino, Avril A. B. Robertson, Mirela Delibegović, Bettina Platt
Topics & Concepts
InflammasomePyrin domainFrontotemporal dementiaNeurodegenerationInflammationDementiaNeuroinflammationMedicinePI3K/AKT/mTOR pathwayInsulin receptorInsulinReceptorNeuroscienceInternal medicineSignal transductionInsulin resistanceBiologyCell biologyDiseaseInflammasome and immune disordersSphingolipid Metabolism and SignalingCholesterol and Lipid Metabolism