Catalytic O<sub>2</sub> activation with synthetic models of α-ketoglutarate dependent oxygenases
Brenda N. Sánchez-Eguía, Joan Serrano‐Plana, Anna Company, Miguel Costas
Abstract
An iron complex bearing the facially capping tridentate 1,4,7-triazacyclononane ligand mimics structural and functional features of alpha-ketoglutarate (α-KG) dependent enzymes, and engages in enzyme-like catalytic O2 activation coupled to α-ketoacid decarboxylation, oxygenating sulfides. This system constitutes a rare case of non-enzymatic catalytic O2 activation, cycling between FeII and FeIV(O).
Topics & Concepts
DecarboxylationOxygenaseCatalysisLigand (biochemistry)ChemistryEnzymeSulfideAlpha ketoglutarateCombinatorial chemistryStereochemistryBiochemistryOrganic chemistryReceptorMetal-Catalyzed Oxygenation MechanismsMicrobial metabolism and enzyme functionMetalloenzymes and iron-sulfur proteins