A portable blood lactate sensor with a non-immobilized enzyme for early sepsis diagnosis
Patcharakorn Kiatamornrak, Siraprapa Boobphahom, Tanat Lertussavavivat, Pranee Rattanawaleedirojn, Orawon Chailapakul, Nadnudda Rodthongkum, Nattachai Srisawat
Abstract
= 0.9937) with a low detection limit of 0.2 mM for lactate detection. This allowed for differentiating patient groups who may have sepsis using a cut-off level of 4 mM. The device was successfully implemented for blood lactate determination in critical patients, showing an accuracy range from 75% to 112%. This device provided high-precision and rapid quantitative information validated using a blood gas analyzer. Our detection kit might help to reduce the morbidity and mortality rates in severe sepsis and septic shock patients in community hospitals.
Topics & Concepts
SepsisSeptic shockBlood lactateMedicineDetection limitIntensive care unitWhole bloodBiomedical engineeringChromatographyChemistryInternal medicineBlood pressureHeart rateElectrochemical sensors and biosensorsElectrochemical Analysis and ApplicationsAnalytical Chemistry and Sensors