Immunosuppressive Property of MSCs Mediated by Cell Surface Receptors
Siyu Liu, Fei Liu, You Lang Zhou, Baeku Jin, Qiang Sun, Shu Guo
Abstract
In the past decade, mesenchymal stem cells (MSCs) tend to exhibit inherent tropism for refractory inflammatory diseases and engineered MSCs have appeared on the market as therapeutic agents. Recently, engineered MSCs target to cell surface molecules on immune cells has been a new strategy to improve MSC applications. In this review, we discuss the roles of multiple receptors (ICAM-1, Gal-9, PD-L1, TIGIT, CD200, and CXCR4) in the process of MSCs' immunosuppressive properties. Furthermore, we discuss the principles and strategies for developing receptor-regulated MSCs and their mechanisms of action and the challenges of using MSCs as immunosuppressive therapies.
Topics & Concepts
Mesenchymal stem cellReceptorProperty (philosophy)Cell biologyMedicineImmunologyBiologyInternal medicinePhilosophyEpistemologyCell Adhesion Molecules ResearchImmunotherapy and Immune ResponsesRNA Interference and Gene Delivery