The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
Laurent Mouchiroud, Riekelt H. Houtkooper, Norman Moullan, Elena Katsyuba, Dongryeol Ryu, Carles Cantó, Adrienne Mottis, Young-Suk Jo, Mohan Viswanathan, Kristina Schoonjans, Leonard Guarente, Johan Auwerx
Topics & Concepts
NAD+ kinaseBiologySirtuinCaenorhabditis elegansTranscription factorCell biologySirtuin 1SIRT3MitochondrionLongevityProteostasisTOR signalingSignal transductionBioenergeticsCofactorBiochemistryGeneticsEnzymeDownregulation and upregulationGeneSirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model OrganismsAdipose Tissue and Metabolism