Intestinal linoleic acid contributes to the protective effects of <i>Akkermansia muciniphila</i> against <i>Listeria monocytogenes</i> infection in mice
Tong Jin, Yingying Zhang, Yanpeng Yang, Yue Teng, Chunhong Yan, Zhongguo Shan, Jianghong Meng, Xiaodong Xia
Abstract
Akkermansia muciniphila pretreatment mitigated Listeria monocytogenes infection in mice. A. muciniphila improved gut microbiota disturbed by L. monocytogenes infection and significantly increased the level of intestinal linoleic acid in mice. Linoleic acid strengthened the intestinal epithelial barrier and reduced pathogen translocation partly by regulating NF-κB/MLCK pathway in a GPR40-dependent manner.
Topics & Concepts
MicrobiologyBiologyListeria monocytogenesPathogenAkkermansia muciniphilaImmune systemImmunologyGut floraBacteriaGeneticsListeria monocytogenes in Food SafetyProbiotics and Fermented FoodsGut microbiota and health