Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells
Yan Huang, Ting Bao, Zhenzhen Li, Guiyi Ji, Li Zhang
Abstract
Lung cancer is the most prevalent type of cancer worldwide and is the leading cause of cancer-associated cases of mortality in the USA and China. Non-small cell lung cancer (NSCLC) accounts for 80-85% of lung cancer cases. microRNAs (miRs) serve multiple roles in the pathogenesis of lung cancer. The current study investigated the lower level of miR-200a in tumor tissues compared with healthy tissue. Overexpression of miR-200a inhibited NSCLC cell proliferation and promoted apoptosis. miR-200a was identified to target Rhophilin Rho GTPase binding protein 2 (RHPN2) and higher levels of RHPN2 were observed in tumor tissues compared with adjacent normal tissues. The current study proposes that miR-200a exhibits a tumor suppressive role in NSCLC and suggests that miR-200a could target RHPN2.