A one-pot stepwise approach to axially chiral quinoline-3-carbaldehydes enabled by iminium–allenamine cascade catalysis
You‐Dong Shao, Dandan Han, Meng-Meng Dong, Xin‐Ru Yang, Dao‐Juan Cheng
Abstract
An organocatalytic atroposelective annulation between 2-(tosylamino)aryl ketones and 2-alkynals for the construction of enantioenriched axially chiral 4-arylquinoline-3-carbaldehydes is achieved.
Topics & Concepts
ChemistryAnnulationIminiumQuinolineCascadeAxial symmetryCatalysisCombinatorial chemistryOrganic chemistryMathematicsChromatographyGeometryAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityAlkaloids: synthesis and pharmacology