Integrating Artificial Intelligence (AI) Chatbots and Green Chemistry Principles in the Synthesis of Cyclohexene
Ji Kim
Abstract
This activity presents a redesigned undergraduate organic chemistry laboratory activity that integrates green chemistry principles and generative artificial intelligence (AI) tools to enhance student learning. Conducted at a two-year college, the activity challenged students to synthesize cyclohexene from cyclohexanol using safer, more sustainable catalysts. Students utilized AI chatbots─such as ChatGPT, Gemini, and Microsoft Copilot─to explore greener alternatives to traditional reagents, aligning their experimental choices with the 12 Principles of Green Chemistry and evaluating their selections with ChemForward and instructor feedback. Catalysts including Amberlyst-15 and dried orange peels were tested, with varying yields, emphasizing the practical challenges and benefits of eco-conscious substitutions. The activity fostered skills in digital literacy, sustainability, and scientific inquiry while promoting awareness of the ethical implications of AI in laboratory decision-making. Survey responses and student reflections showed increased engagement and a deeper understanding of green chemistry. This approach offers a replicable, cost-effective model for embedding sustainability and technology into STEM education while encouraging evidence-based reasoning and critical thinking.