Design, synthesis, molecular simulation, and biological activities of novel quinazolinone-pyrimidine hybrid derivatives as dipeptidyl peptidase-4 inhibitors and anticancer agents
Leila Emami, Zahra Faghih, Amirhossein Sakhteman, Zahra Rezaei, Zeinab Faghih, Farnaz Salehi, Soghra Khabnadideh
Abstract
Twelve novel quinazolinone–pyrimidine hybrids were synthesized, of which some of them showed dual functions as DPP-4 inhibitors and anti-cancer agents.
Topics & Concepts
QuinazolinoneChemistryPyrimidineCombinatorial chemistryBiological activityBiochemistryIn vitroPeptidase Inhibition and AnalysisQuinazolinone synthesis and applicationsSynthesis and Biological Evaluation