Atropisomeric Properties of <i>N</i>-Acyl/<i>N</i>-Sulfonyl 5<i>H</i>-Dibenzo[<i>b</i>,<i>d</i>]azepin-7(6<i>H</i>)-ones
Takuya Namba, Mayuno Hotta, Hidetsugu Tabata, Kosho Makino, Tetsuta Oshitari, Hideaki Natsugari, Hideyo Takahashi
Abstract
-(1,1')-biphenyl-2-yl-glycine derivatives was revisited. It was revealed that the electron-withdrawing property of the amino-protective group was a key to the success of seven-membered cyclization.
Topics & Concepts
ChemistrySulfonylStereochemistryAcylationIntramolecular forceAmidePolar effectMedicinal chemistryOrganic chemistryCatalysisAlkylAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityChemical synthesis and alkaloids